Love motivates 660-lb Donald to begin his weight loss journey.

For Larry, a second weight loss surgery would mean a second chance at a career as a gospel recording artist. But a beautiful singing voice doesn’t pair well with a…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now’s help with a second weight-loss surgery. But just when the…

Having her daughters help bathe her is not how Chrystal pictured parenting, but she is so large now that there’s no other option. Chrystal wants Dr. Now’s help, but she…

Dominic’s life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only…

Kelly is on the verge of immobility when she decided to make the trip to Houston to visit Dr. Now; Her journey gets off to a painful start when a…

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain…

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her; she hopes weight…

Dr. Nowzaradan is worried Lupe’s emotional issues are blocking her weight loss journey since she’s shed over 300 lbs. but still can’t walk. Ashley is struck with sudden paralysis. Sarah…

Tanisha weighs around 600-lbs and she’s desperate to survive for her kids and avoid her mother’s tragic fate of dying at age 50 from super obesity. Now at 32, her…

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can’t stand each other, their father packs up the family to travel across the country…

Cynthia is a 610-lb single mother raising five kids. She’s been focused on her children, but now realizes what her death would mean for them. As she battles her emotions…

Marla is so heavy she cannot stand up. Bedridden, her true weight is unknown but estimated at 800-lbs. Marla must face the facts about her health and the toll it…

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she…

At age 23, and over 600-lbs, Amber relies on her family, and boyfriend for even simple needs. Her fear of dying young is so overwhelming that she makes the decision…