Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won’t survive if he moves to…

Growing up in foster care, David suffered from a lack of attention and didn’t develop a sense of self-worth. Now he weighs 800 pounds, and he’s relying on his favorite…

Lisa wouldn’t have made it this far without the help of her chief enabler, her boyfriend Randy. But Randy falls ill, and Lisa is about to find out if she…

For Larry, a second weight loss surgery would mean a second chance at a career as a gospel recording artist. But a beautiful singing voice doesn’t pair well with a…

Dolly has gotten too comfortable at 600 pounds. There’s physical pain all over, and the skin apron pulling on her abdomen is miserable, but with her mom and others waiting…

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he’s training to become a minister. But if he can’t find a way to…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Living on a homestead with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can’t take off. All he does is eat and game,…

Ryan moved to Montana to keep himself from going down a dark path of drug addiction. However, his new path may be no less lethal than the last if he…

For James B, food means family. He grew up eating rich Haitian food and loves it with a passion. Now, James needs Dr. Now’s help to diminish that love in…

For Julian and his wife, Irma, it was love at first sight. But in order to grow old together, Julian will have to overcome the food addiction that made him…

Bianca is all in for a move to Houston with her boyfriend and two young kids to get Dr. Now’s help with a second weight-loss surgery. But just when the…

Mike was born with a talent for sports — and an omnivorous appetite to match. After his football dreams were dashed by multiple concussions, he packed on over 700 pounds….

Lacey is so big from overeating that she can barely leave the house, but that hasn’t stopped her from finding love with Ricky. Her weight isn’t the only thing between…

When Nathan’s weight gets in the way of the only healthy thing in his life – his job as a drama teacher – it’s a wake-up call for him. But…

Shannon’s husband loves her the way she is, but that may not help because she’s 700 pounds and bedridden. Dr. Now knows it’s not easy to break a toxic cycle…

Isaac helped raise his siblings after his mom suffered a debilitating stroke when he was 10. While learning to cook for his family, he began comfort-eating. Now to avoid eating…

At 600 pounds, Ashley has to move home so her mom can help her care for herself and her newborn daughter; Ashley must overcome a lifetime’s worth of unfortunate circumstances…

J.T. is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn’t change. His girlfriend takes him…

Born as “Matthew,” Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye…

Fearing that he’ll suffer the same fate as older brother David, now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother…

Tanisha weighs around 600-lbs and she’s desperate to survive for her kids and avoid her mother’s tragic fate of dying at age 50 from super obesity. Now at 32, her…

Cynthia is a 610-lb single mother raising five kids. She’s been focused on her children, but now realizes what her death would mean for them. As she battles her emotions…

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event…

At 700lbs, Milla is bedridden and dependent on her husband and five kids. Terrified each day will be her last, they still can’t resist her unending requests for junk food….

At 600 pounds, Lupe spent the last 10 years in bed & totally dependent on her husband. A doctor in Texas is her only hope for change. A cross-country move…

Marla is so heavy she cannot stand up. Bedridden, her true weight is unknown but estimated at 800-lbs. Marla must face the facts about her health and the toll it…