After losing 250 lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki’s progress goes…

A woman’s weight-loss journey is in danger of going off track following the sudden loss of her son; a woman embarks on a plan to win approval for skin surgery.

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses on a new career instead of his diet. With neither brother close to being approved…

Dr. Nowzaradan is worried Lupe’s emotional issues are blocking her weight loss journey since she’s shed over 300 lbs. but still can’t walk. Ashley is struck with sudden paralysis. Sarah…

Brittani will have to endure two more painful surgeries to achieve her ideal body. Will Sean finally make a break from his mother’s over-protective care? And Annette and Calisto prepare…

Surgery enables Teretha to finally return to family in Detroit, but it soon threatens to undo all the progress she’s made. After his weight loss surgery, trucker Chad gets back on…

Tanisha weighs around 600-lbs and she’s desperate to survive for her kids and avoid her mother’s tragic fate of dying at age 50 from super obesity. Now at 32, her…

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey…

Most of the extreme weight on Tracey’s body resides in her shockingly misshapen legs. They’re so massive with severe lymphedema, that gastric surgery is her only chance of survival. Will…

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can’t stand each other, their father packs up the family to travel across the country…

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event…

Growing up in foster care, David suffered from a lack of attention and didn’t develop a sense of self-worth. Now he weighs 800 pounds, and he’s relying on his favorite…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Lacey is so big from overeating that she can barely leave the house, but that hasn’t stopped her from finding love with Ricky. Her weight isn’t the only thing between…

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has online; but not a single one of her profiles is real; Ashley…

When Annjeannette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled…

A 400-lb. woman learns that she’s pregnant, but wonders if she’ll be able to deliver the baby without complications; a woman who lost 400 pounds is in a relationship, but…

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain…

A man who weighed 800 pounds is engaged, but must continue to lose weight; a woman is on the verge of independence if she qualifies for skin surgery.

At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but they are reluctant based on past failures. Each meal threatens Erica’s…

Cynthia is a 610-lb single mother raising five kids. She’s been focused on her children, but now realizes what her death would mean for them. As she battles her emotions…

Lifelong secret eater Nikki finds her life and career as a costume designer threatened by immobility as her weight climbs to 650-lbs. In urgent need of drastic weight loss, she…

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she…

650-lb Melissa struggles to get to her ideal weight.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley’s career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a…

650-lb Melissa begins her seven-year weight loss journey.