Cynthia is a 610-lb single mother raising five kids. She’s been focused on her children, but now realizes what her death would mean for them. As she battles her emotions…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

For Milla Clark, after 3 years and 5 surgeries, success would mean beating the odds, and becoming of on Dr. Nowzaradan’s most impressive weight-loss patients ever, but failure would mean…

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain…

Dr. Nowzaradan is worried Lupe’s emotional issues are blocking her weight loss journey since she’s shed over 300 lbs. but still can’t walk. Ashley is struck with sudden paralysis. Sarah…

Tanisha weighs around 600-lbs and she’s desperate to survive for her kids and avoid her mother’s tragic fate of dying at age 50 from super obesity. Now at 32, her…

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can’t stand each other, their father packs up the family to travel across the country…

After overcoming a dependence on drugs & alcohol, sneaking food is 660-lb Doug’s last remaining vice. Can this husband, and father of 3 overcome his addictive personality and take control…

Michael’s massive 632lb body has left him completely dependent upon his family. If he doesn’t learn to control his anger issues around food, lose weight, and address the root of…

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she…

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and be an active part of her partner and son’s lives….