At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but they are reluctant based on past failures. Each meal threatens Erica’s…

Growing up in foster care, David suffered from a lack of attention and didn’t develop a sense of self-worth. Now he weighs 800 pounds, and he’s relying on his favorite…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Lacey is so big from overeating that she can barely leave the house, but that hasn’t stopped her from finding love with Ricky. Her weight isn’t the only thing between…

Melissa has isolated herself at home and lost many friends to avoid feeling the shame of what her food addiction has done to her body. Now, the only way to…

Ashley is 24 and lives alone; her only sources of comfort are food and the relationships she has online; but not a single one of her profiles is real; Ashley…

Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress; if Jenn and Marissa can’t get…

For Milla Clark, after 3 years and 5 surgeries, success would mean beating the odds, and becoming of on Dr. Nowzaradan’s most impressive weight-loss patients ever, but failure would mean…

A year since her weight loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat…

When Annjeannette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled…

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue…

Ashley hits an emotional wall and is desperate for skin surgery, but she is not losing any weight. After being evicted, Nicole is forced to move back to Ohio, which…

A 400-lb. woman learns that she’s pregnant, but wonders if she’ll be able to deliver the baby without complications; a woman who lost 400 pounds is in a relationship, but…

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain…

After years of a tumultuous relationship with her husband, Tamy’s eating addiction causes her weight to balloon over 500 pounds; she becomes a hermit after years of shame and hopes…

A woman with two children weighs more than 600 pounds, so she agrees to go on an extreme new diet, but her weight-loss efforts are threatened by her debilitating habits…

Surgery enabled Laura’s independence but the complications nearly killed her and she’s terrified about the next skin surgery. Chay revealed to her family she was transgender but living life as…

After losing 250 lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki’s progress goes…

A woman’s weight-loss journey is in danger of going off track following the sudden loss of her son; a woman embarks on a plan to win approval for skin surgery.

Charity manages to lose over 400 pounds, but her daughter Charly becomes dangerously obese. Devastated by the death of her husband, Elroy, Milla must find a way to finally qualify…

A man who weighed 800 pounds is engaged, but must continue to lose weight; a woman is on the verge of independence if she qualifies for skin surgery.

After a year on a weight loss program, Steven remains completely non-compliant, and Justin focuses on a new career instead of his diet. With neither brother close to being approved…

Dr. Nowzaradan is worried Lupe’s emotional issues are blocking her weight loss journey since she’s shed over 300 lbs. but still can’t walk. Ashley is struck with sudden paralysis. Sarah…

Brittani will have to endure two more painful surgeries to achieve her ideal body. Will Sean finally make a break from his mother’s over-protective care? And Annette and Calisto prepare…

Surgery enables Teretha to finally return to family in Detroit, but it soon threatens to undo all the progress she’s made. After his weight loss surgery, trucker Chad gets back on…

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan’s diet program, but…

Tanisha weighs around 600-lbs and she’s desperate to survive for her kids and avoid her mother’s tragic fate of dying at age 50 from super obesity. Now at 32, her…

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey…

Most of the extreme weight on Tracey’s body resides in her shockingly misshapen legs. They’re so massive with severe lymphedema, that gastric surgery is her only chance of survival. Will…

Steven Assanti weighs nearly 800-lbs and his brother/nemesis, Justin, is almost 600-lbs. Though the brothers can’t stand each other, their father packs up the family to travel across the country…

After overcoming a dependence on drugs & alcohol, sneaking food is 660-lb Doug’s last remaining vice. Can this husband, and father of 3 overcome his addictive personality and take control…

Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her home…

Michael’s massive 632lb body has left him completely dependent upon his family. If he doesn’t learn to control his anger issues around food, lose weight, and address the root of…

At 670 pounds Ashley must live in her parents’ home with her husband. Desperate to save her life and her marriage, she decides it’s time for a drastic change. Can…

Cynthia is a 610-lb single mother raising five kids. She’s been focused on her children, but now realizes what her death would mean for them. As she battles her emotions…

Weighing over 600-lbs Kirsten is close to losing her mobility. While she’s trying to get control of her obesity she’s also in danger of losing her troubled son. She must…

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event…

At 650 pounds, Gideon’s weight prohibits him from working, making him completely dependent on his exhausted wife. Desperate for change, he uproots his family to restart his life with weight-loss…

At 650lbs, Randy’s food addiction led to the loss of his marriage and visits with his daughter. To regain control of his life, he endures a rigorous pre-surgery diet, surrounded…