Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her home…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress; if Jenn and Marissa can’t get…

For Milla Clark, after 3 years and 5 surgeries, success would mean beating the odds, and becoming of on Dr. Nowzaradan’s most impressive weight-loss patients ever, but failure would mean…

A year since her weight loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat…

When Annjeannette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled…

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue…

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain…

Surgery enables Teretha to finally return to family in Detroit, but it soon threatens to undo all the progress she’s made. After his weight loss surgery, trucker Chad gets back on…

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan’s diet program, but…

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey…

At 670 pounds Ashley must live in her parents’ home with her husband. Desperate to save her life and her marriage, she decides it’s time for a drastic change. Can…

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she…

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.