A former plus-size model and “big is beautiful” advocate, Renee realizes the mortal mistakes she made as her weight swells to 600 pounds and her health crumbles.

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he’s training to become a minister. But if he can’t find a way to…

Irene had to move back in with her son because her weight made it unbearable to live on her own. When Dr. Now can’t get through to her, the only…

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of, but to break the cycle of pathological eating, he’ll have to…

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially…

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey…

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event…

26-year-old Sean weighs over 700-lbs with a massive growth protruding from his side and skin so stretched it is tearing apart. His mother is forced to change both of their…