Born as “Matthew,” Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye…

At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he’s training to become a minister. But if he can’t find a way to…

Margaret’s life at 700 pounds is in need of a jump start. At age 35, she is a mama’s girl. Now, it’s time for Margaret to get out of bed,…

Paul weighs in at 700 pounds, and his girlfriend struggles with how this limits their ability to live a normal life; he thinks their relationship won’t survive if he moves to…

Ryan moved to Montana to keep himself from going down a dark path of drug addiction. However, his new path may be no less lethal than the last if he…

Mike was born with a talent for sports — and an omnivorous appetite to match. After his football dreams were dashed by multiple concussions, he packed on over 700 pounds….

Shannon’s husband loves her the way she is, but that may not help because she’s 700 pounds and bedridden. Dr. Now knows it’s not easy to break a toxic cycle…

Fearing that he’ll suffer the same fate as older brother David, now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother…

At 700lbs, Milla is bedridden and dependent on her husband and five kids. Terrified each day will be her last, they still can’t resist her unending requests for junk food….