Mike plays Cupid for Mandy by setting her up on a blind-date with Kyle, one of his employees who he thinks would be the perfect guy for her. But Mike’s…

Teddy puts her husband’s life in the hands of her peers when Henry is sent to the OR for surgery and she’s called away on another case; Meredith and Derek…

After being blackballed by most of the surgeons, Meredith uses Lexie to spark Derek’s interest in her patient’s rare brain tumor case and, in secret, gives guidance to April with…

Owen stresses teamwork and moves his leadership role over to the baseball field when he signs the doctors up for a baseball league, pitting them against their biggest competition, Seattle…

The doctors become nostalgic when George O’Malley’s mother, Louise, returns to Seattle Grace for medical help after a botched surgery at a neighboring hospital; the residents are inspired by a…

News of Meredith and Derek’s unsteady relationship raises a red flag for Zola’s adoption counselor; Alex quickly realizes that he has become the outcast of the group after ratting out…

The chief makes a decision that shocks everyone at Seattle Grace; Owen and Cristina attempt to find normalcy; April struggles in her new role; the 5th-year residents receive their first…

A stampede at a comic book convention leads to an influx of colorful characters in the ER; Mark continues to make life difficult for Jackson; Ben returns and realizes Bailey…

The residents try their hardest to impress surgical great Catherine Avery-who also happens to be Jackson’s mother-when she arrives at Seattle Grace to perform a groundbreaking transplant surgery; Arizona and…

The fifth-year residents return for the first day of a year that will make or break their careers: Meredith faces the consequences of tampering with Derek’s clinical trial and is…

Everyone pulls together to help Callie and baby Sofia on their painstaking journeys to recovery in hopes of allowing mother and baby to finally meet; the sudden death of a…

As Callie and Arizona’s wedding approaches, the couple quickly realize that the day they’ve been looking forward to is not turning out the way they’d envisioned. Meanwhile Alex continues to…

Personal and work pressures are adding up and have Meredith visibly on edge, Owen conducts formal interviews for the Chief Resident position, Cristina grows increasingly defiant, Alex and Lucy’s undefined…

News of Meredith’s dishonesty in the clinical trial comes to light, leading to unanticipated consequences for her and others; Cristina finds herself in a compromising situation, which forces her to…

Meredith, looking to prove she is Chief Resident material, learns that anything and everything can happen in an hour’s time when she steps up to run the ER for a…

Meredith must choose between her fertility treatments and her eyesight when she begins having trouble seeing, Mark makes it clear to Callie and Arizona that he takes his role as…

Richard is desperate for Derek and Meredith to accept Adele into their Alzheimer’s trial, but will Adele stand in her own way? Meanwhile Mark and Arizona have conflicting ideas of…

A cataclysmic event leaves the doctors shaken; Callie, on the verge of a life-changing moment, starts imagining about the hospital and her friends.

Arizona tries to reconcile with Callie, who has big news to share; Teddy faces an important decision; the residents receive new interns; the Chief makes an announcement.

Derek breaks ground on his Alzheimer’s clinical trial and Meredith can’t help but feel left out; Bailey’s attempt to take the hospital into the age of new media with live…

Thatcher Grey, Meredith and Lexie’s father, returns to Seattle Grace with stomach pains and a new, twenty-something tattooed girlfriend, Danielle. Meanwhile, Alex clashes with the new OB, Dr. Lucy Fields,…

A gunman opens fire at a local college, sending mass casualties to the hospital; Arizona’s return is not warmly received.

Sam, Dean, and Bobby become actual hunters, in the true sense of the word, when they set up camp in a New Jersey state park to track a creature that…

As Sam and Dean race the clock on a high-stakes mission, Bobby seeks the help of an unlikely old friend to solve one of the most personal cases of his…

Sam and Dean investigate the gruesome murders of resident mediums in Lily Dale, the most “psychic” town in America. They discover that an angry spirit is killing off the psychics…

While on a hunt, Sam runs into someone from his past and a confrontation ensues. Meanwhile, Dean reluctantly teams up with a quirky, laid-back hunter named Garth, when he finds…

Sam and Dean meet Maggie Stark, a witch who has unleashed her wrath on a small town, resulting in numerous deaths. Sam and Dean track down her husband, Donald, to…

Sam and Dean are once again on the FBI’s “Most Wanted” list when two Leviathans clone the brothers and go on a killing spree. The subject of a nationwide manhunt,…

Dean is furious after Sam disappears to follow a lead on a case with clues that are identical to a case Sam solved as a kid. The demon turns out…

Sam and Dean investigate a string of gruesome murders and discover the Egyptian god Osiris is behind the deaths. The vengeful god is putting people on trial for their past…

The broken wall in Sam’s head causes him to have hallucinations, and he has difficulty discerning what’s real and what’s not. Bobby worries that Dean is beginning to stumble under…

Castiel doesn’t kill Sam, Dean and Bobby but warns them not to interfere in his business. Assuming his new role as God, Castiel sets out to right some of the…

Sam, Dean, Bobby and Castiel track Eve to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, they all appear to be…

Castiel tells Sam, Dean and Bobby about the war in Heaven and how he and Raphael became enemies. Bobby believes Castiel is hiding something, but Dean refuses to believe it.

A demon kidnaps Ben and Lisa to get to Dean. Sam and Dean are forced to join with an unlikely ally to free them.

The wall comes down in Sam’s head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced…

While searching for a way to defeat Eve, Dean stumbles upon Samuel Colt’s journal in the Campbell library. Realizing Samuel might have the answer to their problems, Sam and Dean…

Dean and Sam find themselves in an alternate reality where everyone believes they are two actors named Jensen Ackles and Jared Padalecki, who star in a TV show called Supernatural…

Eve, the Mother of All, unleashes a new monster upon the world: a black worm-slug that can enter the brain and force people to kill. Sam and Dean join forces…

After Balthazar changes history and keeps the Titanic from sinking, Fate intervenes and begins killing those that would have died on the ship. Castiel tells Sam and Dean that Fate…